Nurse Practitioner salary in South Carolina
Updated Updated for 2026 tax law
A nurse practitioner in South Carolina earns a median of $123,290 a year ($59.27/hour equivalent), 6.8% below the national median of $132,300. South Carolina ranks #48 of 51 states. About 5,670 people do this job in South Carolina.
Take-home pay in South Carolina
At the South Carolina median, a single filer keeps about $90,077 a year after federal, FICA and South Carolina taxes — $3,465 every two weeks. Try your own numbers with the South Carolina paycheck calculator.
- Gross pay
- $4,741.92
- Federal income tax
- −$704.75
- Social Security (6.2%)
- −$294.00
- Medicare (1.45%)
- −$68.76
- South Carolina income tax
- −$209.90
- Take-home pay
- $3,464.51
Annual breakdown
- Gross
- $123,290
- Federal
- $18,324
- FICA
- $9,432
- State + local
- $5,457
- Net
- $90,077
- Marginal federal rate
- 24.0%
- Marginal state rate
- 5.2%
2026 federal brackets (Rev. Proc. 2025-32) and 2026 state rules. Estimates assume wages are your only income and use annual liability, so your actual withholding can differ slightly.
How South Carolina compares
| Rank | State | Median salary |
|---|---|---|
| #1 | California | $168,520 |
| #2 | New Jersey | $159,310 |
| #3 | Washington | $156,100 |
| #4 | Oregon | $155,680 |
| #5 | Alaska | $155,170 |
| #48 | South Carolina | $123,290 |
| #49 | Kentucky | $122,870 |
| #50 | Tennessee | $117,590 |
| #51 | Alabama | $105,750 |
See the national nurse practitioner salary page for the full pay range and all states.
BLS occupation: Nurse Practitioners (SOC 29-1171), May 2025, state estimates.
Frequently asked questions
How much does a nurse practitioner make in South Carolina?
The median salary is $123,290 a year and the average is $124,170 (BLS May 2025).
Is South Carolina a good state for nurse practitioners?
South Carolina ranks #48 of 51 states for median pay in this job, 7% below the national median of $132,300.
What is $123,290 after taxes in South Carolina?
About $90,077 a year ($3,465 every two weeks) for a single filer in 2026.
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Estimates for information only — not tax, legal or financial advice.