Physician Assistant salary in South Carolina
Updated Updated for 2026 tax law
A physician assistant in South Carolina earns a median of $122,490 a year ($58.89/hour equivalent), 9.9% below the national median of $135,880. South Carolina ranks #45 of 51 states. About 2,250 people do this job in South Carolina.
Take-home pay in South Carolina
At the South Carolina median, a single filer keeps about $89,572 a year after federal, FICA and South Carolina taxes — $3,445 every two weeks. Try your own numbers with the South Carolina paycheck calculator.
- Gross pay
- $4,711.15
- Federal income tax
- −$697.37
- Social Security (6.2%)
- −$292.09
- Medicare (1.45%)
- −$68.31
- South Carolina income tax
- −$208.30
- Take-home pay
- $3,445.08
Annual breakdown
- Gross
- $122,490
- Federal
- $18,132
- FICA
- $9,370
- State + local
- $5,416
- Net
- $89,572
- Marginal federal rate
- 24.0%
- Marginal state rate
- 5.2%
2026 federal brackets (Rev. Proc. 2025-32) and 2026 state rules. Estimates assume wages are your only income and use annual liability, so your actual withholding can differ slightly.
How South Carolina compares
| Rank | State | Median salary |
|---|---|---|
| #1 | New Jersey | $165,690 |
| #2 | California | $165,650 |
| #3 | Washington | $164,360 |
| #4 | Hawaii | $164,050 |
| #5 | New York | $160,880 |
| #45 | South Carolina | $122,490 |
| #49 | Georgia | $115,390 |
| #50 | Mississippi | $105,920 |
| #51 | Alabama | $104,960 |
See the national physician assistant salary page for the full pay range and all states.
BLS occupation: Physician Assistants (SOC 29-1071), May 2025, state estimates.
Frequently asked questions
How much does a physician assistant make in South Carolina?
The median salary is $122,490 a year and the average is $120,720 (BLS May 2025).
Is South Carolina a good state for physician assistants?
South Carolina ranks #45 of 51 states for median pay in this job, 10% below the national median of $135,880.
What is $122,490 after taxes in South Carolina?
About $89,572 a year ($3,445 every two weeks) for a single filer in 2026.
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Estimates for information only — not tax, legal or financial advice.